Science

Dxcover are an award-winning team, dedicated to developing liquid biopsies for early detection of cancer and other diseases. Dxcover technology is based on the world leading research of Matthew J Baker PhD. We spun out from the University of Strathclyde in 2019 as ClinSpec Diagnostics Limited and rebranded as Dxcover Limited in 2021, by which point we had secured £5.1m of funding. We have successfully completed two ground-breaking clinical studies on detection of brain cancer and are currently developing our platform for the detection of commonly occurring cancers.

Featured publications

2021

Early diagnosis of brain tumours using a novel spectroscopic liquid biopsy

Paul M Brennan, Holly J Butler, Loren Christie, Mark G Hegarty...

2020

Biofluid diagnostics by FTIR spectroscopy: A platform technology for cancer detection

A Sala, DJ Anderson, PM Brennan, HJ Butler, JM Cameron, ...
Cancer letters 477, 122-130

2019

Development of high-throughput ATR-FTIR technology for rapid triage of brain cancer

HJ Butler, PM Brennan, JM Cameron, D Finlayson, MG Hegarty, ...
Nature communications 10 (1), 1-9

All publications

2021

Early economic evaluation to guide the development of a spectroscopic liquid biopsy for the detection of brain cancer

E Gray, JM Cameron, HJ Butler, MD Jenkinson, MG Hegarty, DS Palmer, ...
International Journal of Technology Assessment in Health Care 37

2020

Liquid biopsy for cancer diagnosis using vibrational spectroscopy: systematic review

DJ Anderson, RG Anderson, SJ Moug, MJ Baker
BJS open 4 (4), 554

2020

Vibrational spectroscopic analysis and quantification of proteins in human blood plasma and serum

JM Cameron, C Bruno, DR Parachalil, MJ Baker, F Bonnier, HJ Butler, ...
Vibrational Spectroscopy in Protein Research, 269-314

2019

Investigating pre‐analytical requirements for serum and plasma based infrared spectro‐diagnostic

L Lovergne, J Lovergne, P Bouzy, V Untereiner, M Offroy, R Garnotel, ...
Journal of biophotonics 12 (12), e20190017

2019

Development of high-throughput ATR-FTIR technology for rapid triage of brain cancer

HJ Butler, PM Brennan, JM Cameron, D Finlayson, MG Hegarty, ...
Nature communications 10 (1), 1-9

2018

Health economic evaluation of a serum-based blood test for brain tumour diagnosis: exploration of two clinical scenarios

E Gray, HJ Butler, R Board, PM Brennan, AJ Chalmers, T Dawson, ...
BMJ open 8 (5)

2016

Combining random forest and 2D correlation analysis to identify serum spectral signatures for neuro-oncology

BR Smith, KM Ashton, A Brodbelt, T Dawson, MD Jenkinson, NT Hunt, ...
Analyst 141 (12), 3668-3678

2014

Attenuated total reflection Fourier transform infrared (ATR‐FTIR) spectral discrimination of brain tumour severity from serum samples

JR Hands, KM Dorling, P Abel, KM Ashton, A Brodbelt, C Davis, ...
Journal of biophotonics 7 (3‐4), 189-199

2013

Highlighting attenuated total reflection Fourier transform infrared spectroscopy for rapid serum analysis

KM Dorling, MJ Baker
Trends in biotechnology 31 (6), 327-328

2020

Exploring pre-analytical factors for the optimisation of serum diagnostics: Progressing the clinical utility of ATR-FTIR spectroscopy

JM Cameron, HJ Butler, DJ Anderson, L Christie, L Confield, KE Spalding, ...
Vibrational Spectroscopy 109, 103092

2020

Rapid analysis of disease state in liquid human serum combining infrared spectroscopy and “digital drying”

A Sala, KE Spalding, KM Ashton, R Board, HJ Butler, TP Dawson, ...
Journal of Biophotonics 13 (9), e202000118

2020

Interrogation of IDH1 status in gliomas by Fourier transform infrared spectroscopy

JM Cameron, JJA Conn, C Rinaldi, A Sala, PM Brennan, MD Jenkinson, ...
Cancers 12 (12), 3682

2019

Is infrared spectroscopy ready for the clinic?

D Finlayson, C Rinaldi, MJ Baker
Analytical chemistry 91 (19), 12117-12128

2018

Biofluid spectroscopic disease diagnostics: A review on the processes and spectral impact of drying

JM Cameron, HJ Butler, DS Palmer, MJ Baker
Journal of biophotonics 11 (4), e201700299

2016

A review of novel analytical diagnostics for liquid biopsies: spectroscopic and spectrometric serum profiling of primary and secondary brain tumors

K Spalding, R Board, T Dawson, MD Jenkinson, MJ Baker
Brain and behavior 6 (9), e00502

2016

Brain tumour differentiation: rapid stratified serum diagnostics via attenuated total reflection Fourier-transform infrared spectroscopy

JR Hands, G Clemens, R Stables, K Ashton, A Brodbelt, C Davis, ...
Journal of neuro-oncology 127 (3), 463-472

2014

Using Fourier transform IR spectroscopy to analyze biological materials

MJ Baker, J Trevisan, P Bassan, R Bhargava, HJ Butler, KM Dorling, ...
Nature protocols 9 (8), 1771

2020

Stratifying brain tumour histological sub-types: the application of ATR-FTIR serum spectroscopy in secondary care

JM Cameron, C Rinaldi, HJ Butler, MG Hegarty, PM Brennan, ...
Cancers 12 (7), 1710

2020

Shining a light on clinical spectroscopy: Translation of diagnostic IR, 2D-IR and Raman spectroscopy towards the clinic

HJ Butler, JM Cameron, CA Jenkins, G Hithell, S Hume, NT Hunt, ...
Clinical Spectroscopy 1, 100003

2020

Biofluid diagnostics by FTIR spectroscopy: A platform technology for cancer detection

A Sala, DJ Anderson, PM Brennan, HJ Butler, JM Cameron, ...
Cancer letters 477, 122-130

2019

Developing infrared spectroscopic detection for stratifying brain tumour patients: glioblastoma multiforme vs. lymphoma

JM Cameron, HJ Butler, BR Smith, MG Hegarty, MD Jenkinson, K Syed, ...
Analyst 144 (22), 6736-6750

2018

Optimised spectral pre-processing for discrimination of biofluids via ATR-FTIR spectroscopy

HJ Butler, BR Smith, R Fritzsch, P Radhakrishnan, DS Palmer, MJ Baker
Analyst 143 (24), 6121-6134

2016

Biofluid infrared spectro-diagnostics: pre-analytical considerations for clinical applications

L Lovergne, P Bouzy, V Untereiner, R Garnotel, MJ Baker, G Thiéfin, ...
Faraday discussions 187, 521-537

2015

Investigating optimum sample preparation for infrared spectroscopic serum diagnostics

L Lovergne, G Clemens, V Untereiner, RA Lukaszweski, GD Sockalingum, ...
Analytical Methods 7 (17), 7140-7149

2013

Investigating the rapid diagnosis of gliomas from serum samples using infrared spectroscopy and cytokine and angiogenesis factors

JR Hands, P Abel, K Ashton, T Dawson, C Davis, RW Lea, AJS McIntosh, ...
Analytical and bioanalytical chemistry 405 (23), 7347-7355