Science

Dxcover is an award-winning team, dedicated to developing liquid biopsies for early detection of cancer and other diseases. Dxcover technology is based on the world leading research of Matthew J Baker PhD. We spun out from the University of Strathclyde in 2019 as ClinSpec Diagnostics Limited and rebranded as Dxcover Limited in 2021, by which point we had secured £5.1m of funding. We have successfully completed two ground-breaking clinical studies on detection of brain cancer and are currently developing our platform for the detection of commonly occurring cancers.

Featured publications

2021

Early diagnosis of brain tumours using a novel spectroscopic liquid biopsy

Paul M Brennan, Holly J Butler, Loren Christie, Mark G Hegarty...

2020

Biofluid diagnostics by FTIR spectroscopy: A platform technology for cancer detection

A Sala, DJ Anderson, PM Brennan, HJ Butler, JM Cameron, ...
Cancer letters 477, 122-130

2019

Development of high-throughput ATR-FTIR technology for rapid triage of brain cancer

HJ Butler, PM Brennan, JM Cameron, D Finlayson, MG Hegarty, ...
Nature communications 10 (1), 1-9

Conference Presentations

Multi-Cancer Early Detection with a Spectroscopic Liquid Biopsy Platform

ASCO 2022
Chicago, Illinois

2022

All publications

2022

Clinical Validation of a Spectroscopic Liquid Biopsy for Earlier Detection of Brain Cancer

JM Cameron, PM Brennan, G Antoniou, HJ Butler,...
Neurooncology Advances 4(1):vdac024

2021

Early economic evaluation to guide the development of a spectroscopic liquid biopsy for the detection of brain cancer

E Gray, JM Cameron, HJ Butler, MD Jenkinson, MG Hegarty, DS Palmer, ...
International Journal of Technology Assessment in Health Care 37

2020

Biofluid diagnostics by FTIR spectroscopy: A platform technology for cancer detection

A Sala, DJ Anderson, PM Brennan, HJ Butler, JM Cameron, ...
Cancer letters 477, 122-130

2020

Liquid biopsy for cancer diagnosis using vibrational spectroscopy: systematic review

DJ Anderson, RG Anderson, SJ Moug, MJ Baker
BJS open 4 (4), 554

2019

Developing IR spectroscopic detection for stratifying brain tumour patients

JM Cameron, HJ Butler, BR Smith, ...
Analyst 144 (22), 6736-6750

2019

Development of high-throughput ATR-FTIR technology for rapid triage of brain cancer

HJ Butler, PM Brennan, JM Cameron, D Finlayson, MG Hegarty, ...
Nature communications 10 (1), 1-9

2018

Health economic evaluation of a serum- based blood test for brain tumour diagnosis: exploration of two clinical scenarios

E Gray, HJ Butler, R Board, PM Brennan, AJ Chalmers, T Dawson, ...
BMJ open 8 (5)

2016

Biofluid infrared spectro-diagnostics: pre-analytical considerations for clinical applications

L Lovergne, P Bouzy, V Untereiner, R Garnotel, MJ Baker, G Thiéfin, ...
Faraday discussions 187, 521-537

2014

Attenuated total reflection Fourier transform infrared (ATR‐FTIR) spectral discrimination of brain tumour severity from serum samples

JR Hands, KM Dorling, P Abel, KM Ashton, A Brodbelt, C Davis, ...
Journal of biophotonics 7 (3‐4), 189-199

2013

Investigating the rapid diagnosis of gliomas from serum samples using infrared spectroscopy and cytokine and angiogenesis factors

JR Hands, P Abel, K Ashton, T Dawson, C Davis, RW Lea, AJS McIntosh, ...
Analytical and bioanalytical chemistry 405 (23), 7347-7355

2021

Clinical Spectroscopy: Lost in Translation?

JM Cameron, C Rinaldi, SH Rutherford, A Sala,...
Applied Spectroscopy

2020

Shining a light on clinical spectroscopy: Translation of diagnostic IR, 2D-IR and Raman spectroscopy towards the clinic

HJ Butler, JM Cameron, CA Jenkins, G Hithell, S Hume, NT Hunt, ...
Clinical Spectroscopy 1, 100003

2020

Exploring pre analytical factors for the optimisation of serum diagnostics: Progressing the clinical utility of ATR-FTIR spectroscopy

JM Cameron, HJ Butler, DJ Anderson, L Christie, L Confield, KE Spalding, ...
Vibrational Spectroscopy 109, 103092

2020

Rapid analysis of disease state in liquid human serum combining infrared spectroscopy and “digital drying”

A Sala, KE Spalding, KM Ashton, R Board, HJ Butler, TP Dawson, ...
Journal of Biophotonics 13 (9), e202000118

2019

Is infrared spectroscopy ready for the clinic?

D Finlayson, C Rinaldi, MJ Baker
Analytical chemistry 91 (19), 12117-12128

2018

Optimised spectral pre-processing for discrimination of biofluids via ATR-FTIR spectroscopy

HJ Butler, BR Smith, R Fritzsch, P Radhakrishnan, DS Palmer, MJ Baker
Analyst 143 (24), 6121-6134

2016

Combining random forest and 2D correlation analysis to identify serum spectral signatures for neuro-oncology

BR Smith, KM Ashton, A Brodbelt, T Dawson, MD Jenkinson, NT Hunt, ...
Analyst 141 (12), 3668-3678

2016

A review of novel analytical diagnostics for liquid biopsies: spectroscopic and spectrometric serum profiling of brain tumors

K Spalding, R Board, T Dawson, MD Jenkinson, MJ Baker
Brain and behavior 6 (9), e00502

2014

Using Fourier transform IR spectroscopy to analyze biological materials

MJ Baker, J Trevisan, P Bassan, R Bhargava, HJ Butler, KM Dorling, ...
Nature protocols 9 (8), 1771

2021

Rapid Spectroscopic Liquid Biopsy for the Universal Detection of Brain Tumours

AG Theakstone, PM Brennan, MD Jenkinson,...
Cancers 13(15): 3851

2020

Vibrational spectroscopic analysis and quantification of proteins in human blood plasma and serum

JM Cameron, C Bruno, DR Parachalil, MJ Baker, F Bonnier, HJ Butler, ...
Vibrational Spectroscopy in Protein Research, 269-314

2020

Stratifying brain tumour histological sub-types: the application of ATR-FTIR serum spectroscopy in secondary care

JM Cameron, C Rinaldi, HJ Butler, MG Hegarty, PM Brennan, ...
Cancers 12 (7), 1710

2020

Interrogation of IDH1 status in gliomas by Fourier transform infrared spectroscopy

JM Cameron, JJA Conn, C Rinaldi, A Sala, PM Brennan, MD Jenkinson, ...
Cancers 12 (12), 3682

2019

Investigating pre‐ analytical requirements for serum and plasma based infrared spectro‐diagnostic

L Lovergne, J Lovergne, P Bouzy, V Untereiner, M Offroy, R Garnotel, ...
Journal of biophotonics 12 (12), e20190017

2018

Biofluid spectroscopic disease diagnostics: A review on the processes and spectral impact of drying

JM Cameron, HJ Butler, DS Palmer, MJ Baker
Journal of biophotonics 11 (4), e201700299

2016

Brain tumour differentiation: rapid stratified serum diagnostics via ATR-FTIR spectroscopy

JR Hands, G Clemens, R Stables, K Ashton, A Brodbelt, C Davis, ...
Journal of neuro-oncology 127 (3), 463-472

2015

Investigating optimum sample preparation for infrared spectroscopic serum diagnostics

L Lovergne, G Clemens, V Untereiner, RA Lukaszweski, GD Sockalingum, ...
Analytical Methods 7 (17), 7140-7149

2013

Highlighting attenuated total reflection Fourier transform infrared spectroscopy for rapid serum analysis

KM Dorling, MJ Baker
Trends in biotechnology 31 (6), 327-328

Product & Application  Notes

The Dxcover Platform is the next-generation of infrared analysis, with the potential to transform the routine analyses of a range of samples. For more information, please see our portfolio of Application Notes. 

Cannabidiol Quantification Using the Dxcover Infrared Platform
Application Note
Dxcover Infrared Platform for Process Analytics
Application Note
Upstream Bioprocess Monitoring Using Next Generation ATR-FTIR Spectroscopy
Application Note
Product Note
Dxcover Infrared Biofluid Analysis Platform